Both control and intervention groups showed improvements in global cognition and in all cognitive domains after 1 year, but differences in cognitive changes between the two groups were not statistically significant. Results: After the 1-year follow-up, 571 (89.1%) controls and 573 (89.8%) from the intervention group participated in the post-intervention assessment. Cognitive changes as a function of the intervention were analyzed with multivariable mixed-effects models. Global cognition (measured with MMSE and CERAD-total score), and five cognitive domains (perceptual speed, executive function, episodic memory, verbal abilities, and constructional praxis) were created. The raw scores from the CERAD subtests and the single tests were standardized into Z-scores. Cognitive function was ascertained at baseline and at 1-year follow-up with the Consortium to Establish a Registry for Alzheimer's Disease (CERAD)-Neuropsychological Battery and five additional domain-specific single cognitive tests. Adherence to the NU-AGE diet was measured over follow-up, and categorized into tertiles (low, moderate, high). Participants were randomly allocated into two groups: “control” ( n = 638), following a habitual diet and, “intervention” ( n = 641), given individually tailored dietary advice (NU-AGE diet).
#Type2 board vendor name 1 type2 board product name15 trial#
Materials and Methods: NU-AGE randomized trial (NCT01754012, ) included 1279 relatively healthy older-adults, aged 65–79 years, from five European centers. In this study, we specifically investigated the effects of NU-AGE's dietary intervention on age-related cognitive decline. NU-AGE is the first multicenter intervention assessing whether a diet targeting health in aging can counteract the age-related physiological changes in different organs, including the brain. However, to establish diet-neuroprotective causal relations, evidence from dietary intervention studies is needed. 10Institute of Neurological Sciences (IRCCS), Bologna, Italyīackground: Findings from animal and epidemiological research support the potential neuroprotective benefits from healthy diets.Galvani,” University of Bologna, Bologna, Italy 8Centre Hospitalier Universitaire de Clermont-Ferrand, Clermont-Ferrand, France.7Norwich Medical School, University of East Anglia, Norwich, United Kingdom.6Department of Human Nutrition, Warsaw University of Life Sciences - SGGW, Warsaw, Poland.
5Division of Human Nutrition, Wageningen University & Research, Wageningen, Netherlands.4Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.3Stockholm Gerontology Research Center, Stockholm, Sweden.2Department of Epidemiology and Biostatistics, School of Public Health, Tianjin Medical University, Tianjin, China.
0 kommentar(er)
